Review Article

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Year: 2022 I Volume: 4 I Issue: 1I Pages I 

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Microsatellite Instability Testing Approaches in Clinical Practice: A comparative Review

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Nagwa Ibrahim 1, Huda Mokhtar 2, Ashraf Farrag 2

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1Prince Sultan Military Medical City, Department of Pharmaceutical Services, Riyadh, Saudi Arabia

2Prince Sultan Military Medical City, Department of Adult Oncology, Riyadh, Saudi Arabia

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* Corresponding Author:

Nagwa Ibrahim, Pharm D, PhD

Email address: nag_ibrahim@hotmail.com 

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Source of funding:  None

 

Conflict of interest: None

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Key wards: Microsatellite Instability, MSI-H, dMMR, detection approaches, Lynch syndrome

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Abstract:

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Immunotherapy development particularly with PD-1 inhibitors, has changed the treatment paradigm for certain types of cancer. The group of malignancies that are characterized by deficiency in the mismatch repair (dMMR) / microsatellite instability high (MSI-H) is an example and are highly sensitive to PD-1 blockade. MSI testing and analysis of MMR expression play an important role in the detection of patient's eligibility to immunotherapy, prognosis and chemotherapy sensitivity. Here our target is to comparatively review and summarize the published research results about MSI testing approaches to provide a guidance easily utilized in oncology clinical practice.